Ookami Kodomo No Ame To Yuki

Hana is a 19-year-old student who falls in a "fairy-tale like" love with a "wolf man". Over the course of the 13-year story Hana gives birth to two children—older sister Yuki, and younger brother Ame, or "Snow and Rain". At first the family quietly lives in city trying to hide their wolf heritage, but when the "wolf man" suddenly dies Hana makes the decision to move to a rural town, far from their previous city life. - ANN